Fungal immunology, host-pathogen interactions, regulated cell death, microbiology.
|Shlezinger Lab Website||Zuckerman STEM leadership program page|
Senior Lecturer, Koret School of Veterinary Medicine,
Robert H. Smith Faculty of Agriculture, Food, and Environment, The Hebrew University of Jerusalem, Rehovot.
|2014-2019||Postdoctoral Fellow, Memorial Sloan Kettering Cancer Center, New York, NY.|
|2009-2014||Ph.D., George S. Wise Faculty of Life Sciences, Tel Aviv University.|
|2007-2009||M.S., summa cum laude, George S. Wise Faculty of Life Sciences, Tel Aviv University.|
|2003-2006||B.S., George S. Wise Faculty of Life Sciences, Tel Aviv University|
The global burden associated with human fungal pathogens is estimated at 1 billion infections and over 1.6 million deaths annually. This mortality rate is similar to that of tuberculosis and >3-fold more than malaria. The increasing burden of fungal disease in the world, together with the emergence of drug resistant organisms is an alarming challenge to medicine and human health.
The Shlezinger lab uses multidisciplinary approach to address two broad questions: what are the mechanisms that enable fungi to overcome immune surveillance and cause infectious diseases and, conversely, how the host immune response can protect against fungal pathogens. The projects in the lab address common questions in pathogenesis and immunology at the molecular, cellular and whole-organism level.
To decode these intricate interactions, we generate functional reporters of fungal physiology and apply cross-disciplinary single-cell analysis techniques to monitor the outcome of individual fungal cell-host encounters within the complexities of in vivo environment.