Selected Publications

School Contact Information

Koret School of Veterinary Medicine,
The Robert H. Smith Faculty of Agricultural, Food & Environment,
The Hebrew University of Jerusalem.

Address: Herzl 229, P.O. Box 12,
Rehovot 76100, Israel

Phone: +972-(0)8-9489021/31;
Fax: +972-(0)8-9467940
E-Mail: vet.school@mail.huji.ac.il

 

Harrus, S., Kenny, M., Miara, L., Aizenberg, I., Waner, T. and Shaw, S. (2004). Comparison of simultaneous splenic sample PCR with blood sample PCR for iagnosis and treatment of experimental Ehrlichia canis infection. Antimicrob. Agents Chemother. 48:4488-4490.

Harrus, S. and Baneth, G. (2005). Drivers for the emergence and reemergence of vector-borne protozoal and rickettsial organisms. Int. J. Parasitol. 35:1309-1318.

Bauer, O., Baneth, G., Eshkol, T., Shaw, S. and Harrus, S. (2006). Poly-genic detection of Rickettsia felis in cat fleas (Ctenocephalides felis) from Israel. Am. J. Trop. Med. Hyg. 74:444-448.

Harrus, S., Lior, Y., Ephros, M., Grisaru-Soen, G., Keysary, A., Strenger, C., Jongejan, F., Waner, T., Baneth, G. (2007). Rickettsia conorii in humans and dogs: a seroepidemiological survey of two rural villages in Israel. Am. J. Trop. Med. Hyg. 77:133-135.

Shipov, A., Klement, E., Reuveni-Tager, L., Waner, T. and Harrus, S. 2008. Prognostic indicators for canine monocytic ehrlichiosis. Vet. Parasitol. 153:131-138.

Baneth, G., Harrus, S., Ohnona,F.S., and Schlesinger Y. 2009. Longitudinal quantification of Ehrlichia canis in experimental infection with comparison to natural infection. Vet. Microbiol. 136:321-5.

Or, M., Samish, M., Waner, T. and Harrus, S. 2009. Attenuation of Ehrlichia canis by multiple-passages in 2 different cultures. Clin. Microbiol. Infect. 15:74-75.

Morick, D., Osinga, N., Gruys, E. and Harrus, S. 2009. Identification of a Bartonella species in the harbor seal (Phoca vitulina) and in seal lice (Echinophtirius horridus). Vector Borne Zoonotic Dis. 9:751-753.

Harrus, S., Kahila Bar-Gal, G., Golan, A., Elazari-Volcani, R., Kosoy, M., Morick, D., Avidor, B., Baneth, G. 2009. Isolation and genetic characterization of a genotype closely related to Bartonella tribocorum and Bartonella elizabethae in Israeli wild rats. Am. J. Trop. Med. Hyg. 81:55-58.

Morick, D., Baneth, G., Avidor, B., Kosoy, M. Y., Mumcuoglu, K. Y., Mintz, D.C, Eyal, O., Goethe, R., Mietze, A., Shpigel, N., Harrus, S. 2009. Detection of Bartonella spp. in wild rodents in Israel using HRM real-time PCR. Vet. Microbiol. 139:293-297.

Peleg, O., Baneth, G., Eyal, O., Inbar, J. and Harrus S. 2009. The use of chimeric DNA/RNA primers in quantitative PCR for the detection of Ehrlichia canis and Babesia canis Appl. Environ. Microbiol. 19:6393-6398.

Ohad, D. G., Morick, D., Avidor, B., Harrus, S. 2009. Molecular detection of Bartonella henselae and Bartonella koehlerae from aortic valves of Boxer dogs with infective endocarditis. Vet. Microbiol. 141:182-185.

Peleg, O., Baneth, G., Eyal, O., Inbar, J. and Harrus, S. 2010. Multiplex real time qPCR for the detection of Ehrlichia canis and Babesia canis vogeli. Vet. Parasitol. 173:292-299.

Morick, D., Krasnov, B. R., Khokhlova, I. S., Shenbrot, G. I., Kosoy, M. Y., Harrus, S. 2010. Bartonella genotypes in fleas (Insecta: Siphonaptera) collected from rodents in the Negev Desert, Israel. Appl. Environ. Microbiol. 76:6864-6869.

Harrus, S., Waner, T. 2011. Diagnosis of canine monocytotropic ehrlichiosis: An overview. Vet. J. 187:292-296.

Harrus, S., Perlman-Avrahami, A., Mumcuoglu, K. Y., Morick, D., Baneth, G. 2011. Molecular detection of Rickettsia massiliae, Rickettsia sibirica mongolitimonae and Rickettsia conorii israelensis in ticks from Israel. Clin. Microbiol. Infect. 17:176-180.

Harrus, S., Perlman-Avrahami, A., Mumcuoglu, K. Y., Morick, D., Eyal. O., Baneth, G. 2011. Molecular detection of Ehrlichia canis, Anaplasma bovis, Anaplasma platys, Candidatus Midichloria mitochondrii and Babesia canis vogeli in ticks from Israel. Clin. Microbiol. Infect. 17:459-463.

Mietze, A., Morick, D. , Köhler, H., Harrus, S., Nolte, I., Goethe, R. 2011. Combined MLST and AFLP typing of Bartonella henselae isolated from cats reveals new sequence types and suggests clonal evolution. Vet. Microbiol. 148:238-245.

Morick, D., Krasnov, B. R., Khokhlova, I. S., Gottlieb, Y., Harrus, S. 2011. Investigation of Bartonella acquisition and transmission in Xenopsylla ramesis fleas (Siphonaptera: Pulicidae). Mol. Ecol. 20:2864-2870.

Mylonakis, M. E., Ceron, J. J., Leontides, L., Siarkou, V. I., Martinez, S., Tvarijonaviciute, A., Koutinas, A. F., Harrus, S. 2011. Serum acute phase proteins in naturally-occurring canine monocytic ehrlichiosis (Ehrlichia canis). J. Vet. Int. Med. 25:811-817.

Lalzar, I.S, Harrus, S.C, Mumcuoglu, K.C, and Gottlieb, Y. 2012. Composition and seasonal variation of Rhipicephalus turanicus and Rhipicephalus sanguineus bacterial communities. Appl. Environ. Microbiol. 78:4110-6

Rudoler, N. Baneth, G. Eyal, O. van Straten, M. Harrus, S. (2012). Evaluation of an attenuated strain of Ehrlichia canis as a vaccine for Canine Monocytic Ehrlichiosis. Vaccine, 31: 226-233.

Morick, D., Krasnov, B. R., Khokhlova, I. S., Gottlieb, Y. and Harrus, S. (2013). Transmission dynamics of Bartonella species OE 1-1 in Sundevall's Jirds (Meriones crassus). Appl. Environ. Microbiol. 79:1258-1264.

Theodorou, K., Mylonakis, M., Siarkou, V., Leontides, L., Koutinas, A., Koutinas, C., Kritsepi- Konstantinou, M., Batzias, G., Flouraki, E., Eyal, O., Kontos, V., Harrus, S. (2013). Efficacy of rifampin in the treatment of experimental acute canine monocytic ehrlichiosis. J. Antimicrob. Chemoth. 68:1619-26.

Kamani, J., Baneth, G., Mumcuoglu, K. Y., Waziri, N. E., Eyal, O., Guthmann, Y., Harrus, S.(2013). Molecular detection and characterization of tick-borne pathogens in dogs and ticks from Nigeria. PLoS Neglect. Trop. Dis. 7(3):e2108. doi: 10.1371.

Amram, E., Freed, M., Khateb, N., Mikula, I., Blum, S., Spregser, J., Sharir, B., Ozeri, R., Harrus, S. Lysniansky, I. (2013). Multiple locus variable number tandem repeat analysis of Mycoplasma bovis isolated from local and imported cattle. Vet. J. 197:286-290.

Morick, D., Krasnov, B. R., Khokhlova, I. S., Gutiérrez, R., Fielden, L. J., Gottlieb, Y. and Harrus, S. (2013). Effects of Bartonella on feeding and reproductive performance of fleas. Appl. Environ. Microbiol. 79:3438-3443.

Waner, T. and Harrus, S. (2013). Canine monocytic ehrlichiosis - from pathology to clinical manifestations. Isr. J. Vet. Med. 68:12-18.

Kleinerman, G., Baneth, G., Mumcuoglu, K. Y., van Straten, M,, Berlin, D., Apanaskevich, D. A., Abdeen, Z., Nasereddin, A., Harrus, S. (2013). Molecular detection of Rickettsia africae, Rickettsia aeschlimannii and Rickettsia sibirica mongolitimonae in camels and Hyalomma spp. ticks from Israel. Vector Borne Zoonotic Dis. 13:851-856.

Kamani, J., Morick, D., Morick, Mumcuoglu, K. Y., Harrus, S. (2013). Prevalence and diversity of Bartonella species in commensal rodents and ectoparasites from Nigeria, West Africa. PLoS Neglect. Trop. Dis. 7(5):e2246.

Gutiérrez, R., Morick, D., Gross, I., Winkler, R., Abdeen, Z., Harrus, S. (2013). Bartonella in domestic and stray cats from Israel – Comparison of Bacterial cultures and HRM real time PCR as diagnostic methods. Vector Borne Zoonotic Dis. 13:857-864.

Morick, D., Krasnov, B. R., Khokhlova, I. S., Gutiérrez, R., J., Gottlieb, Y. and Harrus, S. (2013). Vertical non-transovarial transmission of Bartonella in fleas. Mol. Ecol. 18:4747-4752.

Mylonakis, M. E., Xenoulis, P. G., Theodorou, K., Siarkou, V.I., Steiner, J. M., Harrus, S., Leontides, L., Rallis, T., Suchodolski, J. S., Koutinas, C., Koutinas, A. F. (2014). Serum canine pancreatic lipase immunoreactivity in experimentally-induced and naturally-occurring canine monocytic ehrlichios (Ehrlichia canis). Vet. Microbiol. 169:198-202.

Lerner, U., Amram, E., Ayling, R. D., Mikula, I., Gerchman, S., Harrus, S., Teff, D., Yogev, D., Lysniansky, I. (2014). Acquired resistance to the 16-membered macrolides tylosin and tilmicosin by Mycoplasma bovis. Vet. Microbiol. 168:365-371.

Gutiérrez, R., Morick, D., Cohen, C., Hawlena, H., and Harrus, S. (2014). The effect of ecological and temporal factors on the composition of Bartonella infection in rodents and their fleas. The ISME Journal 8:1598-1608.

Kamani, J., Baneth, G., Mitchell, M., Mumcuoglu, K. Y., Gutiérrez, R., Harrus, S. (2014). Bartonella species in bats (Chiroptera) and bat flies (Nycteribiidae) from Nigeria, West Africa. Vector Borne Zoonotic Dis. 14:625-632.

Gutiérrez, R., Cohen, L., Morick, D., Mumcuoglu, K. Y., Harrus, S. and Gottlieb, Y. (2014). Identification of different Bartonella species in the cattle tail louse Haematopinus quadripertusus and in cattle blood. Appl. Environ. Microbiol. 80:5477-5483.

Nasereddin, A., Risheq, A., Harrus, S., Azmi, K., Ereqat, S., Baneth, G., Salant, H., Mumcuoglu, K.Y., Z. Abdeen. (2014). Bartonella species in fleas from Palestinian territories: Prevalence and genetic diversity. J. Vector Ecol. 39:261-270.

Waner, T., Nachum-Biala, Y., Harrus, S. (2014). Evaluation of a commercial in-clinic point-of-care polymerase chain reaction test for Ehrlichia canis DNA in artificially infected dogs. Vet. J. 202:618-21.

Amram, E., Mikula, I., Schnee, C., Ayling, R. D., Nicholas, R. A. J., Rosales, R. S., Harrus, S., Lysnyansky, I. (2015). Presence of 16S rRNA gene mutations associated with acquired decreased susceptibility to tetracycline in Mycoplasma bovis. Antimicrob. Agents Chemother. 59:796-802.

Baneth, G., Harrus, S. Gal, A., Aroch, I. (2015). Canine vector-borne co-infections: Ehrlichia canis and Hepatozoon canis in the same host monocytes. Vet. Parasitol. 208:30-34.

Sainz, Á., Roura, X., Miró, G., Estrada-Peña, A., Kohn, B., Harrus, S., Solano-Gallego, L. (2015). Guideline for veterinary practitioners on canine ehrlichiosis and anaplasmosis in Europe. Parasit. Vectors. 8:75. doi: 10.1186/s13071-015-0649-0.

Gutiérrez, R., Krasnov, B. R., Morick, D., Gottlieb, Y. Khokhlova, I. S. Harrus, S. (2015). Bartonella infection in rodents and their flea ectoparasites – An overview. Vector Borne Zoonotic Dis. 15:27-39.

Sofer, S., Gutiérrez, R., Morick, D., Mumcuoglu, K., Harrus, S. Molecular detection of zoonotic bartonellae (B. henselae, B. elizabethae and B. rochalimae) in fleas collected from dogs in Israel. Med. Vet. Entomol. doi: 10.1111/mve.12116.

Kamani, J., Baneth, G., Apanaskevich, D. A., Mumcuoglu, K. Y., Harrus, S. (2015). Molecular detection of Rickettsia aeschlimannii in Hyalomma spp. ticks from camels (Camelus dromedarius) in Nigeria, West Africa. Med. Vet. Entomol. 29:205-209.

Rzotkiewicz, S., Gutiérrez, R., Krasnov, B. R., Morick, D., Khokhlova, I. S., Nachum-Biala, Y., Baneth, G., Harrus, S. (2015). Novel evidence suggests that a "Rickettsia felis-like" organism, is an endosymbiont of the desert flea, Xenopsylla ramesis. Mol. Ecol. 24:1364-1373.

Theodoro, K., Leontides, L., Siarkou, V. I., Petanides, T., Tsafas, K., Harrus, S., Mylonakis, M. E. Synovial fluid cytology in experimental acute canine monocytic ehrlichiosis (Ehrlichia canis). Vet. Mic. 177:224-227.

Rudoler, N., Harrus, S., Martinez-Subiela, S., Tvarijonaviciute, A., van Straten, M., Ceron, J., Baneth, G. (2015). Comparison of the acute phase protein and antioxidant responses in dogs vaccinated against canine monocytic ehrlichiosis and naive-challenged dogs. Parasit. Vectors. 8:175. doi: 10.1186/s13071-015-0798-1.

Harrus, S. (2015). Perspectives on the pathogenesis and treatment of canine monocytic ehrlichiosis (Ehrlichia canis). Vet. J. doi: 10.1016/j.tvjl.2015.04.027.

Rojas, N., Troyo, A., Castillo, D., Gutiérrez, R., Harrus, S. (2015). Molecular detection of Bartonella species in fleas collected from dogs and cats from Costa Rica. Vector Borne Zoonotic Dis. 15: 630-632.

Gutiérrez, R., Nachum-Biala, Y., Harrus, S. (2015). Relationship between the presence of Bartonella species and bacterial loads in cats and cat fleas (Ctenocephalides felis) under natural conditions Appl. Environ. Microbiol. 81:5613-5621.

Kandelaki, G., Malania, L., Bai, Y., Chakvetadze, N., Katsitadze, G., Imnadze, P., Nelson, C., Harrus, S., Kosoy, M. (2016). A Case of human lymphadenopathy and fever linked to a rat-associated Bartonella strain related to B. tribocorum and B. elizabethae, Tbilisi, Country of Georgia. Emerg. Infect. Dis. 22:544-546. doi: 10.3201/eid2203.151823.

Ereqat, S., Nasereddin, A., Al-Jawabreh, A., Azmi, K., Harrus, S., Mumcuoglu, K., Apanaskevich, D., Abdeen, Z. (2015). Molecular Detection and identification of spotted fever group rickettsiae in ticks collected from the West Bank, Palestinian Territories.PLoS Negl. Trop. Dis. 2016 Jan 15;10(1):e0004348. doi: 10.1371/journal.pntd.0004348.

Marciano, O., Gutiérrez, R., Morick, D., King, R., Nachum-Biala1, Y., Baneth, G., Harrus, S. 2016. Detection of Bartonella spp. in wild carnivores, hyraxes, hedgehog and rodents from Israel. Parasitology. 143: 1232-1242.

Kamani, J., Baneth, G., Gutiérrez, R., Nachum-Biala, Y., Salant, H., Mumcuoglu, KY., Harrus, S. 2015. Molecular screening of Ctenocephalides felis fleas collected from stray cats in the Jerusalem District, Israel, for Bartonella spp., Rickettsia spp. and Coxiella burnetiiVeterinary Parasitology: Regional Studies and Reports. 1–2, 59–64, doi: 10.1016/j.vprsr.2016.04.001

Amram, E., Borovok, I., Nachum-Biala, Y., Ayling, R., Lerner, U., Harrus, S., Lysnyansky, I. 2016. High Prevalence of Diverse Insertion Sequences within the Ribosomal RNA Operons of Mycoplasma bovisAppl. Environ. Microbiol. 82:6386-6394.

Gutiérrez, R., Buffet, J. F., Vayssier-Taussat, M., Harrus, S. 2017. Guidelines for the isolation, molecular detection and characterization of Bartonella species. Vector Borne Zoonotic Dis. 17:42-50.

Rose, J.,Nachum-Biala1, Y., Mumcuoglu, KY., Alkhamis, MA., Ben-Nun, A. Lensky, I., Klement, E., Nasereddin, A., Abdeen, ZA., Harrus, S. 2017. Genetic characterization of spotted fever group rickettsiae in questing ixodid ticks collected in Israel and environmental risk factors for their infection. Parasitology. 144: 1088-1101.

Müller, A., Monti, G., Otth. C., Sepúlveda, P., Bittencourt, P., Nachum-Biala, Y., Gutiérrez, R., Harrus, S. 2017.Candidatus Neoehrlichia chilensis’ sp. nov.: Molecular detection and characterization of a novel Anaplasmataceae in wild rodents from Valdivia, Southern Chile.         Transbound. Emerg. Dis. 65: 357-362.

Kamani, J, Baneth, G., Gutiérrez, R., Nachum-Biala, Y., Mumcuoglu, KY., Harrus, S. 2018. Coxiella burnetii and Rickettsia conorii: two zoonotic pathogens in peridomestic rodents and their ectoparasites in Nigeria. Ticks Tick Borne Dis. 9: 86-92.

Kamani, J., Harrus, S., Nachum-Biala, Y., Salant, H., Mumcuoglu, KY, Baneth, G. 2018. Pathogenic and endosymbiont apicomplexans in Ctenocephalides felis (Siphonaptera: Pulicidae) from cats in Jerusalem, Israel. Comparative Immunology, Microbiology & Infectious Diseases. Comp. Immunol. Microbiol. Infect Dis.. 57:29-33.

Helan, JNVG., Grinberg, A., Gedye, K., Potter, M., Harrus, S. 2018. Molecular detection of  Bartonella coopersplainsensis and Bartonella henselae in rats from New Zealand. New Zealand Vet. J. 6:1-8.

Gutiérrez, R., Cohen, C., Flatau, R., Marcos-Hadad, E., Garrido, M., Halle, S., Nachum-Biala, Y., Covo, S., Hawlena, H., Harrus, S. 2018. Untangling the knots: co-infection and diversity of Bartonella from wild gerbils and their associated fleas. Mol. Ecol. 27:4787-4807.

Gutiérrez, R., Markus, B., Carstens Marques de Sousa, K., Marcos-Hadad, E., Mugasimangalam, RC., Nachum-Biala, Y., Hawlena, H., Covo, S., Harrus, S. 2018. Prophage-driven genomic structural changes promote Bartonella vertical evolution. Genome Biol. Evol. 10:3089-3103.

Mylonakis, M.E., Harrus, S., Breitschwerdt, E.B. 2019. An update on the treatment of canine monocytic ehrlichiosis (Ehrlichia canis). Vet J. 246:45-53.

André MR, Gutiérrez R, Ikeda P, do Amaral RB, de Sousa KCM, Nachum-Biala Y, Lima L, Teixeira  MMG, Machado RZ, Harrus S. 2019. Genetic diversity of Bartonella spp. in vampire bats from Brazil. Transbound Emerg Dis. 66(6):2329-2341. doi: 10.1111/tbed.13290.

Eidelman A, Cohen C, Navarro-Castilla Á, Filler S, Gutiérrez R, Bar-Shira E, Shahar N, Garrido M, Halle S, Romach Y, Barja I, Tasker S, Harrus S, Friedman A, Hawlena H. 2019. The dynamics Between limited-term and lifelong coinfecting bacterial parasites in wild rodent hosts. J Exp Biol. 222(Pt 15). pii:jeb203562. doi: 10.1242/jeb.203562.

Gutierrez R., Shalit T., Markus B., Yuan C., Nachum-Biala Y., Elad D., Harrus S. 2020 Bartonella kosoyi sp. nov. and Bartonella krasnovii sp. nov., two novel species closely related to the zoonotic Bartonella elizabethae, isolated from black rats and wild desert rodent-flea. IJSEM, doi: 10.1099/ijsem.0.003952.        

Berkowitz A., Harrus S., Gutiérrez, R., Nachum-Biala, Y., Busnach, S., Green, E., Davidoff, A., Klainbart, S. and Waner, T. 2020. Bartonella henselae-associated myocarditis in cats. First report in Israel. Israel J Vet Med. 75:42-45.

Gonçalves, LR., Harrus S., Gutiérrez, R., Herrera, HM., de Souza Ramos, IA., de Oliveira Porfírio, GE., Nachum-Biala, Y., Marques de Sousa, KC., da Silva, TMV., Campos, JBV., Barros-Battesti, DM., Zacarias Machado, R., André, MR. 2020. Molecular detection and genetic diversity of Bartonella species in large ruminants and associated ectoparasites from the Brazilian Cerrado. Transbound Emerg Dis. doi: 10.1111/tbed.13517.

Gonçalves, LR., Harrus, S., Herrera, HM., Gutiérrez, R., Pedrassani, D., Gimenes Nantes, A., Martins Santos, F., de Oliveira Porfirio, GE., Gomes Bareto, WT., Macedo, GC., de Oliveira Assis, W., Vilela Campos, JB., Silva, TMV., Biolchi, J., Sousa, KCM., Nachum Biala, Y., Barros-Battesti, DM., Zacarias Machado, R., André, MR. 2020. Low occurrence of Bartonella in synanthropic mammals and associated ectoparasites in peri-urban areas from Central-Western and Southern Brazil. Acta Tropica. 105513. doi: 10.1016/j.actatropica.2020.105513.

Harrus, S., Canine vaccination guidelines in Israel. Israel J Vet Med. 75: 111-121.

Müller, A., Gutiérrez, R., Seguel, M.  Monti, G., Otth. C., Bittencourt, P., Sepúlveda, P., Alabí, A.,  Nachum-Biala, Y., Harrus, S. 2020. Molecular survey of Bartonella spp. in rodents and fleas from Chile. Acta Tropica. 212:105672. doi: 10.1016/j.actatropica.2020.105672.

Power, RI., Davies, NE., Nachum Biala, Y., Salant, H., Harrus, S., Šlapeta, J. 2021. Adaptation of gltA and ssrA assays for diversity profiling by Illumina sequencing to identify Bartonella henselaeB.clarridgeiae and B. koehleraeJ Medical Microbiol. DOI 10.1099/jmm.0.001400

Majerová, K., Gutiérrez, R., Fonville, M., Hönig, V., Papežík, P., Hofmannová, L., Lesiczka, PM., Nachum-Biala, Y., Ruzek, D., Sprong, H., Harrus, S., Modrý, D., Votýpka, J. 2021. Hedgehogs and squirrels as hosts of zoonotic Bartonella specie. Pathogens. 10, 686. https://doi.org/10.3390/pathogens10060686

Kamani, J., Harrus, S., Ocholi, RA., Yague, II., Nyango, PG., González-Miguel, J., Koizumi, N.  Molecular detection and characterization of pathogenic Leptospira species in bats (Chiroptera) roosting in human habitats in Nigeria, West Africa. Zoonoses and Public Health. In press.

Gutiérrez, R., Ram, Y., Berman, J., Carstens Marques de Sousa, K., Nachum-Biala, Y., Britzi, M., Elad, D., Glaser, G., Covo, S., Harrus, S. 2021. Adaptive resistance mutations at supra-inhibitory concentrations independent of SOS mutagenesis. Mol Biol Evol. doi: 10.1093/molbev/msab196.

 

 

For the full list of publications go to the following link: https://www.ncbi.nlm.nih.gov/pubmed/?term=harrus+s

See also: shimon_harrus