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Selected Recent Publications | Koret School of Veterinary Medicine
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Selected Recent Publications

School Contact Information

Koret School of Veterinary Medicine,
The Robert H. Smith Faculty of Agricultural, Food & Environment,
The Hebrew University of Jerusalem.

Address: Herzl 229, P.O. Box 12,
Rehovot 76100, Israel

Phone: +972-(0)8-9489021/31;
Fax: +972-(0)8-9467940
E-Mail: vet.school@mail.huji.ac.il

 

  1. Page LE, Kubai MA, Allbaugh RA, Bedos L, Roy MM, Mochel JP, Sebbag L. Increased drug concentration and repeated eye drop administration as strategies to optimize topical drug delivery: A fluorophotometric study in healthy dogs. Vet Ophthalmol. 2023 Jul;26(4):331-338.  doi: 10.1111/vop.13125.
  2. Leonard BC and Sebbag L. Ocular Surface Diseases. Vet Ophthalmol. 2023 Apr;26 Suppl 1:4. doi: 10.1111/vop.13099. Epub 2023 Apr 25.
  3. Handel K, Ofri R, Sebbag L. Accuracy of data in abstracts of veterinary ophthalmology research articles published in peer-reviewed journals. Vet Ophthalmol 2023 Mar 9:393-397. (online ahead of print).
  4. Bedos L, Allbaugh RA, Roy M, Kubai MA, Sebbag L. Precorneal retention time of ocular lubricants measured with fluorophotometry in healthy dogs. Vet Ophthalmol. 2023 Apr;26 Suppl 1:81-88. doi: 10.1111/vop.13065. Epub 2023 Feb 7.
  5. Shiraishi H, Vernau KM, Kim S, Good KL, Hollingsworth SR, Sebbag L, Montgomery E, Surmick JD, Freeman KS, Choi E, Casanova IM, Maggs DJ. Symblepharon in kittens: a retrospective study of 40 kittens and 54 eyes (2002–2022). J Fel Med Surg 2023 Feb;25(2):1098612X221150160.
  6. Sarfaty H, Ezra-Elia R, Kahane N, Sandalon S, Segev Y, Sebbag L. Standard modified glabellar flap for medial canthus reconstruction following mass removal in three dogs and two cats. Vet Ophthalmol. 2023 Mar;26(2):121-127. doi: 10.1111/vop.13070. Epub 2023 Mar 5.
  7. Sebbag L and Sanchez R. The pandemic of ocular surface disease in brachycephalic dogs: the Brachycephalic Ocular Syndrome. Vet Ophthalmol. 2023 Apr;26 Suppl 1:31-46. doi: 10.1111/vop.13054. Epub 2022 Dec 31.
  8. Iwashita H, Sebbag L, Leonard BC, Saito A. A review of diagnostic tests for qualitative and quantitative tear film deficiency in dogs. Vet Ophthalmol. 2023 Apr;26 Suppl 1:5-15. doi: 10.1111/vop.13044. Epub 2022 Dec 27.
  9. Oksa-Minalo J, Maggs DJ, Akimova J, Ilgaza A, Sebbag L. Ocular surface physiology and aqueous tear production in cats of diverse cephalic conformations. Vet Ophthalmol. 2023 Apr;26 Suppl 1:109-118. doi: 10.1111/vop.13051. Epub 2022 Dec 15.
  10. Bedos L, Wickham H, Gabriel V, Zdyrski C, Allbaugh RA, Sahoo DK, Sebbag L, Mochel JP, Allenspach K. Culture and characterization of canine and feline corneal epithelial organoids: A new tool for the study and treatment of corneal diseases. Front. Vet Sci 2022 Nov 4;9:1050467. doi: 10.3389/fvets.2022.1050467. eCollection 2022.
  11. Sebbag L, Souza Martins da Silva AP, Pereira Barbosa dos Santos A, Raposo AC, Oriá A. An eye on the Shih Tzu dog: Ophthalmic exam findings and ocular surface diagnostics. Vet Ophthalmol. 2023 Apr;26 Suppl 1:59-71. doi: 10.1111/vop.13022. Epub 2022 Sep 3.
  12. Bowden AC, Allbaugh RA, Smith JS, Mochel JP, Sebbag L. Kinetics and minimal inhibitory concentrations of ceftiofur in tear film following extended-release parenteral administration (Excede®) in dogs. Front. Vet Sci 2022 Sep 20;9:975113. doi: 10.3389/fvets.2022.975113. eCollection 2022.
  13. Wilcox P, Strong T, Sebbag L, Allbaugh RA. Effect of topical nitric oxide-donors 0.03% nitroglycerin and 0.1% hydralazine on intraocular pressure in healthy canine eyes. Vet Med Sci. 2022.
  14. Sarfaty H, Ezra-Elia R, Sebbag L. Prevalence and characteristics of ocular diseases in Sphinx cats: A retrospective assessment (2012-2021) and comparison with non-Sphinx cats. Vet Ophthalmol 2022.
  15. Park S, Sebbag L, Moore B et al (10 authors). Multimodal ocular imaging of known and novel corneal stromal disorders in dogs. BMC Vet Res 18, 117 (2022).
  16. Arad D, Komoron S, Pe’er O, Sebbag L, Ofri R. Mucoadhesive polymers enhance ocular drug delivery: Proof of concept study with 0.5% tropicamide in dogs. J Ocul Pharm Ther. 2021 (Online ahead of print). 2.671; 25/61 (Ophthalmology).
  17. Sebbag L, Broadbent VL, Kenne DE, Perrin AL, Mochel JP. Albumin in tears modulates bacterial susceptibility to topical antibiotics in ophthalmology. Front. Med. 2021. 5.093; 28/167 (Medicine, General & Internal).
  18. Kreuder AJ, Allbaugh RA, Sebbag L. Letter to the Editor: Comparison of antimicrobial resistance patterns in dogs with bacterial keratitis presented to a veterinary teaching hospital over two multi-year time periods (1993–2003 and 2013–2019) in the Southeastern United States. Vet Ophth 2021. 1.644; 62/146 (Veterinary Sciences).
  19. Arad D, Deckel R, Pe’er O, Ross M, Sebbag L, Ofri R. Is it necessary to wait several minutes between applications of different topical ophthalmic solutions? A preliminary study with tropicamide eye drops in healthy dogs. Vet Ophth 2021 Aug 17 (Online ahead of print). 1.644; 62/146 (Veterinary Sciences).
  20. O’Leary LM, Allbaugh RA, Schrunk DE, Olsen TE, Sebbag L. Variable accuracy, precision, and consistency of compounded famciclovir formulated for management of feline herpesvirus-1 in cats. Vet Ophthalmol. 2021 Jun 12 (Online ahead of print). 1.644; 62/146 (Veterinary Sciences).
  21. O’Leary LM, Sebbag L, Moody LM, Diehl KA, Allbaugh RA. Acute corneal hydrops of presumed traumatic origin: An uncontrolled case series (three horses). Equine Vet. Educ. 2021. 1.063; 95/146 (Veterinary Sciences).
  22. Romaneck A, Sebbag L. Clinical remission in a cat with severe bilateral eosinophilic keratitis receiving combined immunosuppressive therapy (triamcinolone acetonide and tacrolimus. Frontiers in Vet Sci, 2021. 2.245; 19/141 (Veterinary Sciences).
  23. Foote BC, Smith JS, Bowden AC, Allbaugh RA, Sebbag L. Successful management of refractory keratomycosis in an alpaca using penetrating keratoplasty and combination antifungal therapy (caspofungin 0.5% and terbinafine 1%). Front Vet Sci. 2021. 2.245; 19/141 (Veterinary Sciences).
  24. Sebbag L, Thomasy SM, Leland A, Mukai M, Kim S, Maggs DJ. Altered corneal innervation and ocular surface homeostasis in FHV-1-exposed cats: A preliminary study suggesting metaherpetic disease. Front Vet Sci. 2021 Jan 26;7:580414. 2.245; 19/141 (Veterinary Sciences).
  25. Bertram M, Allbaugh RA, Mochel JP, Peraza J, Page L, Sebbag L. Influence of Schirmer strip wetness on volume absorbed, volume recovered, and total protein content in canine tears. Vet Ophthalmol. 2021 Mar 15. 1.015; 73/141 (Veterinary Sciences).
  26. Uhl LK, Henriksen ML, Saxmose Nielsen S, Gemensky-Metzler AJ, Sebbag L, Todd JM. Cataracts and phacoemulsification in the Siberian Husky: A retrospective and multicentric study (2008-2018). Vet Ophthalmol. 2021 Mar 17. 1.015; 73/141 (Veterinary Sciences).
  27. Gentile D, Allbaugh RA, Adiguzel MC, Kenne DE, Sahin O, Sebbag L. Bacterial cross-contamination in a veterinary ophthalmology setting. Front Vet Sci. 2020 Dec 23;7:571503. 2.245; 19/141 (Veterinary Sciences).
  28. Foote BC, Smith JD, Allbaugh RA, Sebbag L. Histologic effects of MicroPulse™ transscleral cyclophotocoagulation in normal equine eyes. Vet Ophthalmol. 2021 Jan;24(1):59-70. 1.015; 73/141 (Veterinary Sciences).
  29. Lucyshyn DR, Good KL, Knickelbein KE, Chang MW, Strøm AR, Hollingsworth SR, Thomasy SM, Leonard BC, Sebbag L, Wiggans KT, Maggs DJ. Subcutaneous administration of triamcinolone as part of the management of feline eosinophilic keratoconjunctivitis. J Feline Med Surg. 2020 Nov 3. 1.393; 51/141.
  30. Sebbag L, Mochel JP. An eye on the dog as the scientist's best friend for translational research in ophthalmology: Focus on the ocular surface. Med Res Rev. 2020 Nov;40(6):2566-2604. 9.30; 8/271 (Pharmacology and Pharmacy).
  31. Sebbag L, Mochel JP. Pharmacokinetics of oral prednisone at anti-inflammatory to immuno-suppressive doses in dogs: A naïve pooled-data approach. Frontiers in Vet Sci, 2020. 2.245; 19/142 (Veterinary Sciences).
  32. Hewitt JS, Allbaugh RA, Kenne DE, Sebbag L. Prevalence and antibiotic susceptibility of bacterial isolates from dogs with ulcerative keratitis in Midwestern United States.  Frontiers in Vet Sci, 2020. 2.245; 19/142 (Veterinary Sciences).
  33. Sebbag L Kirner N, Wulf L, Mochel JP. Tear film pharmacokinetics and systemic absorption of topical 1% prednisolone acetate ophthalmic suspension in dogs. Frontiers in Vet Sci, 2020. 2.245; 19/142 (Veterinary Sciences).
  34. Sebbag L, Soler EA, Allbaugh RA, Mochel JP. Impact of acute conjunctivitis on ocular surface homeostasis in dogs. Vet Ophthalmol. 2020 Sep;23(5):828-833. 1.105; 73/142 (Veterinary Sciences). #Wiley top cited article 2020-2021
  35. Page L, Allbaugh RA, Mochel JP, Peraza J, Bertram M, Sebbag L. Impact of diurnal variation, sex, tear collection method, and disease state on tear protein levels in dogs. Vet Ophthalmol 2020 Nov;23(6):994-1000. 1.105; 73/142 (Veterinary Sciences). Wiley top cited article 2020-2021
  36. Mansour TA, Woolard K, Ancona D, Vernau L, Thomasy SM, Sebbag L, Moore BA, Knipe M, Cowan T, Aguilar M, Brown CT, Bannasch DL. Whole genome sequencing for mutation discovery in a single case of lysosomal storage disease (MPS type 1) in the dog. Sci Rep. 2020 Apr 16;10(1):6558. 3.998; 17/71 (Multidisciplinary Sciences).
  37. Sebbag L, Uhl L, Schneider B, Hayes B, Olds J, Mochel JP. Investigation of Schirmer tear test-1 for measurement of tear production in cats under various environmental settings and test durations. J Am Vet Med Assoc, 2020 Mar 15;256(6):681-686. 1.303; 39/142 (Veterinary Sciences).
  38. Terhaar H, Allbaugh RA, Mochel JP, Sebbag L. Serum albumin and total protein concentration in the tear film of horses with healthy or diseased eyes. Vet Ophthalmol 2020. 1.105; 73/142 (Veterinary Sciences).
  39. Bolzanni H, Oria A, Raposo AC, Sebbag L. Aqueous tear assessment in dogs: impact of cephalic conformation, inter-test correlations and test-retest repeatability. Vet Ophthalmol. 2020 May;23(3):534-543. 1.105; 73/142 (Veterinary Sciences).
  40. Sebbag L, Moody LM, Mochel JP. Albumin levels in tear film modulate the bioavailability of medically-relevant topical drugs. Front. Pharmacol 2020; Jan 28;10:1560. 3.845; 59/267 (Pharmacology & Pharmacy).
  41. Foote BC, Sebbag L. Diagnosis and Treatment of Ocular Proptosis. Today’s Veterinary Practice, January/February 2020.
  42. Sebbag L, Kirner NS, Allbaugh RA, Reis A, Mochel JP. Kinetics of fluorescein in tear film after eye drops instillation in Beagle dogs: Does size really matter? Front Vet Sci 2019; Dec 19;6:457. 2.029; 18/141 (Veterinary Sciences).
  43. Sebbag L, Moody LM, Allbaugh RA, Mochel JP. Nerve growth factor in dogs: Assessment of two immunoassays and selected ocular parameters following nicergoline challenge per os. Vet Ophthalmol 2020; 23(1):199-204. 1.105; 73/142 (Veterinary Sciences).
  44. Allbaugh RA, Wehrman RF, Sebbag L. Comparison of topical 0.05% difluprednate to 1% prednisolone acetate in inhibiting paracentesis-induced blood aqueous barrier breakdown in healthy dogs. Am J Vet Res. 2020 Mar;81(3):260-266. 1.07; 65/141 (Veterinary Sciences).
  45. Sebbag L, Riggs A, Carnevale J. Oculo-skeletal dysplasia in 5 Labrador Retrievers. Vet Ophthalmol. 2020 Mar;23(2):386-393. 1.105; 73/142 (Veterinary Sciences).
  46. Sebbag L, Crabtree EE, Sapienza JS, Kim K, Rodriguez E. Corneal hypoesthesia, aqueous tear deficiency and neurotrophic keratopathy following micropulse transscleral cyclophotocoagulation in dogs. Vet Ophthalmol. 2020 Jan;23(1):171-180. 1.105; 73/142 (Veterinary Sciences).
  47. Sebbag L, Allbaugh RA, Wehrman RF, Uhl LK, Ben-Shlomo G, Chen T, Mochel JP. Fluorophotometric assessment of tear volume and turnover rate in healthy dogs and cats. J Ocul Pharmacol Ther 2019; 35(9):497-502. 1.792; 30/59 (Ophthalmology).
  48. Sebbag L, Yan Y, Smith JS, Allbaugh RA, Wulf LW, Mochel JP. Tear fluid pharmacokinetics following oral prednisone administration in dogs with and without conjunctivitis. J Ocul Pharmacol Ther 2019;  35(6):341-349. 1.792; 30/59 (Ophthalmology).
  49. Sebbag L, Allbaugh RA, Weaver A, Seo YJ, Mochel JP. Histamine-induced conjunctivitis and breakdown of blood-tear barrier in dogs: A model for ocular pharmacology and therapeutics. Front. Pharmacol. 2019;10:752. 3.845; 59/267 (Pharmacology & Pharmacy).
  50. Lerch M, Allbaugh RA, Sebbag L, Mochel JP, Weller P, Borts DJ. Paper Spray High–Resolution Accurate Mass Spectrometry for Quantitation of Voriconazole in Equine Tears. Anal Bioanal Chem. 2019 May 23. 3.286; 18/84 (Chemistry, Analytical).
  51. Foote BC, Smith JS, Allbaugh RA, Sebbag L, Ben-Shlomo G. Novel use of a combination of extracellular matrices for wound healing following resection of a large inferior eyelid mass in a miniature Hereford. J Am Vet Med Assoc. 2020 Oct 15;257(8):833-839. 1.303; 39/142 (Veterinary Sciences).
  52. Wehrman RF, Sebbag L, Reilly CM, Allbaugh RA, Ben-Shlomo G, et al. (2019) Richter’s Syndrome as an Ocular Manifestation of Systemic Disease in a Dog: A Case Report. J Vet Med Surg. Vol. 2 No. 1:22.
  53. Moore BA, Leonard BC, Sebbag L, et al (43 authors). Identification of genes required for eye development by high-throughput screening of mouse knockouts. Communications Biology (Nature), December 21 2018 (ePub). N/A.
  54. Uhl L, Akihiko S, Iwashita H, Maggs DJ, Mochel JP, Sebbag L. Clinical features of cats with aqueous tear deficiency: A retrospective case series of 10 patients (17 eyes). J Feline Med Surg. 2018 Nov 12:1098612X18810867. 1.584; 39/141 (Veterinary Sciences).
  55. Feye KM, Smith JS, Sebbag L, Hohman AE, Acharya S, et al. Veterinary considerations for the theoretical resurrection of extinct species. J Vet Sci Ani Husb 2018; 6(3): 309. N/A.
  56. Sebbag L, Allbaugh RA, Strauss RA, Strong TD, Wehrman RF, Foote BC, Ben-Shlomo G. MicroPulseTM transscleral cyclophotocoagulation in the treatment of canine glaucoma: preliminary results (12 dogs). Vet Ophthalmol. 2018; Aug 15. 1.083; 62/140 (Veterinary Sciences).
  57. Oria AP, Reboucas MF, Filho EM, des Assis Dorea Neto F, Raposo AC, Sebbag L. Photography-based method for assessing fluorescein clearance test in dogs. BMC Vet Res. 2018; 14:269. 1.958; 20/140 (Veterinary Sciences).
  58. Strauss RA, Genschel U, Allbaugh RA, Sebbag L, Ben-Shlomo G. Evaluation of microbial contamination of canine plasma eyedropper bottles following clinical use in canine patients. Vet Ophthalmol. 2018 May 24. 1.083; 62/140 (Veterinary Sciences).
  59. Sebbag L, Showman L, McDowell EM, Perera A, Mochel JP. Impact of flow rate, collection devices and extraction methods on tear concentrations following oral administration of doxycycline in dogs and cats. J Ocul Pharmacol Ther, 2018; 34 (6): 452-459. 1.921; 30/59 (Ophthalmology). 
  60. Moore BA, Roux M, Sebbag L, et al. A Population Study of Common Ocular Abnormalities in C57BL/6N Rd8 Mice. Invest Ophthalmol Vis Sci, 2018, May 1;59(6):2252-2261. 3.812; 9/59 (Ophthalmology).
  61. Sebbag L, McDowell EM, Hepner PM, Mochel JP. Effect of tear collection on lacrimal total protein content in dogs and cats: a comparison between Schirmer strips and ophthalmic sponges. BMC Vet Res. 2018, 14(1):61. 1.958; 20/140 (Veterinary Sciences).
  62. Sebbag L, Allbaugh RA, Strong TD, Strauss RA, Wehrman RF, Foote BC, Peterson C, Ben-Shlomo B. Lack of effect of a topical regenerative agent on re-epithelialization rate of canine spontaneous chronic corneal epithelial defects: A randomized, double-masked, placebo-controlled study. Vet J. 2018, 233:63-65. 1.773; 26/140 (Veterinary Sciences).
  63. Sebbag L, Pesavento PA, Carrasco SE, Reilly CM, Maggs DJ. Feline dry eye syndrome of presumed neurogenic origin: a case report. JFMS Open Reports. 2018 Jan 2; 4(1):2055116917746786. N/A.
  64. Sebbag L, Harrington DM, Mochel JP. Tear fluid collection in dogs and cats using ophthalmic sponges. Vet Ophthalmol. 2018; 21(3):249-254. 1.083; 62/140 (Veterinary Sciences).
  65. Sebbag L, Park SA, Kass PH, et al. Assessment of tear film osmolarity using the TearLab™ osmometer in normal dogs and dogs with keratoconjunctivitis sicca. Vet Ophthalmol. 2017; 20(4):357-364. 0.959; 61/136 (Veterinary Sciences).
  66. Sebbag L, Reilly CM, Eid R, Maggs DJ. Goblet cell density and distribution in cats with clinically and histologically normal conjunctiva. Vet Ophthalmol. 2016 Jul;19 Suppl 1:38-43. 0.959; 61/136 (Veterinary Sciences).
  67. Sebbag L, Thomasy SM, Woodward AP, Knych HK, Maggs DJ. Pharmacokinetic modeling of penciclovir and BRL42359 in the plasma and tears of healthy cats to optimize dosage recommendations for oral administration of famciclovir. Am J Vet Res. 2016 Aug;77(8):833-45. 1.004; 58/136 (Veterinary Sciences).
  68. Sebbag L, Kass PH, Maggs DJ. Reference values, intertest correlations, and test-retest repeatability of selected tear film tests in healthy cats. J Am Vet Med Assoc. 2015 Feb 15;246(4):426-35. 1.501; 32/137 (Veterinary Sciences).
  69. Sebbag L, Harkin KR, Habekost A, Gumber S, Lee T. Abdominal chronic expanding hematoma causing iron-deficiency anemia in a dog. J Am Anim Hosp Assoc. 2014 Sep-Oct;50(5):350-5. 0.862; 71/136 (Veterinary Sciences).
  70. Sebbag L, Smee N, van der Merwe D, Schmid D. Liver failure in a dog following suspected ingestion of blue-green algae (Microcystis spp.): a case report and review of the toxin. J Am Anim Hosp Assoc. 2013 Sep-Oct;49(5):342-6. 0.783; 77/132 (Veterinary Sciences).
  71. Rankin AJ, Sebbag L, Bello NM, Crumley WR, Allbaugh RA. Effects of oral administration of anti-inflammatory medications on inhibition of paracentesis-induced blood-aqueous barrier breakdown in clinically normal cats. Am J Vet Res. 2013 Feb;74(2):262-7. 1.214; 45/132 (Veterinary Sciences).
  72. Van der Merwe D, Sebbag L, Nietfeld JC, Aubel MT, Foss A, Carney E. Investigation of a Microcystis aeruginosa cyanobacterial freshwater harmful algal bloom associated with acute microcystin toxicosis in a dog. J Vet Diagn Invest. 2012 Jul;24(4):679-87. 1.181; 53/143 (Veterinary Sciences).
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